2019 Water Disinfection, Byproducts, and Health GRC/GRS

题为“水消毒、副产品和健康：通过先进的多学科方法寻找与消毒副产品相关的新问题的解决方案”的2019年戈登研究会议将于2019年7月27日至8月2日在马萨诸塞州南哈德利的Mount Holyoke学院举行。本次会议将接替由早期职业科学家组织的为期1.5天的戈登研究研讨会（GRS）。GRS将由研究生和博士后进行演讲，并为年轻的专业人士提供指导小组。在2019年的GRC/GRS上，来自世界各地的学者、监管机构、研究生、博士后、工业科学家和水专业人士等约160名与会者将展示前沿研究成果，以应对提供可持续安全饮用水的挑战。饮用水消毒是上个世纪预防水传播疾病的主要公共卫生成就之一。包括水供应受到污染和日益减少在内的多种全球性问题需要创新技术来有效处理新的和现有的水源，以便向消费者提供安全的饮用水。不同的水源（例如受生活或工业废水影响的水源）需要不同的消毒策略，因此产生不同类型和数量的消毒副产物（DBPs）。在选择消毒处理工艺时，许多自来水公司优先考虑减少特定dbp，以符合监管准则。然而，产生低水平调控dbp的处理过程可能会产生更高浓度的其他毒性更强的dbp。这对平衡微生物和化学品风险提出了新的挑战。流行病学研究表明，DBP暴露与膀胱癌和结直肠癌风险增加以及不良发育影响存在潜在关联。然而，对观察到的健康影响负责的dbp仍不清楚。虽然已经确定了数百种dbp，但大多数仍然是未知的和未分类的。这些知识差距给选择处理策略、监测水质、评估健康风险和改进监管准则带来了巨大挑战。2019年GRC/GRS的目标是：(1)通过整合先进的分析和毒理学测试技术，填补在识别与健康相关的未知dbp方面的知识空白；(2)更好地了解DBP的形成和转化机制，设计创新的消毒方案，以更好地控制DBP；(3)讨论暴露和流行病学评估的最新进展，以完善未来的指导方针。工程、化学、毒理学、流行病学和监管政策等领域的前沿研究将有助于实现保护人类健康的中心目标。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The 2019 Gordon Research Conference entitled "Water Disinfection, By-Products, and Health: Finding Solutions to Emerging Issues Related to Disinfection Byproducts by Advanced Multidisciplinary Approaches" will be held at Mount Holyoke College in South Hadley, MA on July 27-August 2, 2019. The Conference will succeed a 1.5-day Gordon Research Seminar (GRS), organized by early career scientists. The GRS will feature presentations by graduate students and postdoctoral fellows, and a mentoring panel for young professionals. At the 2019 GRC/GRS, about 160 participants including academics, regulators, graduate students, postdoctoral fellows, industrial scientists, and water professionals from around world will present cutting-edge research to address challenges in providing sustainable safe drinking water. Disinfection of drinking water is one of the major public health achievements to prevent waterborne-diseases in the last century. Multiple global issues, including contaminated and diminishing water supplies, demand innovative technologies for effective treatment of new and existing water sources to provide safe drinking water to consumers. Different source waters (e.g., those impacted by domestic or industrial wastewater) require different disinfection strategies and therefore generate different types and amounts of disinfection byproducts (DBPs). When choosing disinfection treatment processes, many water utilities prioritize the reduction of specific DBPs to comply with regulatory guidelines. However, a treatment process that yields low levels of the regulated DBPs may produce higher concentrations of other more toxic DBPs. This raises new challenges in balancing microbial and chemical risks. Epidemiological studies have shown potential associations of DBP exposure with increased risk of bladder and colorectal cancers as well as adverse developmental effects. However, the DBPs responsible for the observed health effects remain unclear. Although hundreds of DBPs have been identified, the majority are still unknown and unclassified. These knowledge gaps present tremendous challenges in choosing treatment strategies, monitoring water quality, assessing health risks, and improving regulatory guidelines. The objectives of the 2019 GRC/GRS are (1) to fill the knowledge gap in identifying unknown DBPs of health relevance by integrating advanced analytical and toxicological testing technologies; (2) to get a better understanding of the mechanisms of DBP formation and transformation to engineer innovative disinfection schemes for better control of DBPs; (3) to discuss recent advances in exposure and epidemiological assessment for improving future guidelines. The cutting-edge research in the fields of engineering, chemistry, toxicology, epidemiology and regulatory policy will contribute to the central goal of protection of human health.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.