EAGER: Nanostructured porous and laminate coatings for biodegradable magnesium-based implants with tunable water permeability and improved mechanical properties

生物可降解镁基合金被认为是一种很好的植入材料，无需额外的二次手术取出植入物。它们重量轻，具有接近骨骼的物理和机械性能，具有优异的生物相容性和骨整合性，并且它们可以完全降解并被自然再生的骨骼所取代。然而，裸镁基植入物的安装经常伴随着高初始腐蚀速率和氢释放爆裂，这可能导致各种术后并发症。因此，其实施的成功高度依赖于腐蚀速率和氢释放的控制，特别是在安装的初始阶段。这种功能可以通过具有良好控制的透水性的特殊涂层来提供。该项目支持对生物可降解镁植入物的未经测试但可能具有变革性的想法进行探索性工作。它正在探索一种新的工艺方法和潜在的机制，在一个新的“薄膜涂层概念可调水运输”-通过涂层组件，能够提供有针对性的/可调的吸收或降解时间。它将研究如何将薄的，可降解的和纳米多孔层结合到纳米层压涂层中，可以显着扩展对镁基植入物初始腐蚀速率的可调控制。该项目还支持在HBCU为URM学生提供最先进的科学和技术培训，沿着更深入地接触基于团队的研究和价值创造的最佳实践。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

Biodegradable Mg-based alloys are considered as a great material for implantation without additional secondary surgery for implant removal. They are lightweight, have close to bones physical and mechanical properties, excellent biocompatibility and osseointegration, and they can completely degrade and be replaced by naturally re-grown bones. However, installation of bare Mg-based implants has frequently been accompanied with high initial corrosion rate and hydrogen release burst that can cause variety of post-surgical complications. Therefore, the success of their implementation highly depends on control of corrosion rate and hydrogen release especially during the initial stage of installation. This function can be provided by special coatings having well-controlled water permeability. This project supports exploratory work on an untested, but potentially transformative idea for biodegradable Mg implants. It is exploring a new process methodology and underlying mechanism in a new "thin film coatings concept for tunable water transport" - through coating components that are capable of providing targeted/tunable resorption or degradation time. It will study how combining thin, degradable and nanoporous layers into nanolaminate coatings can significantly extend tunable control of initial corrosion rate of Mg-based implants. This project also supports providing URM students at an HBCU with state-of-the-art science and technology training, along with deeper exposure to team-based research and value-creation best practices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.