Phase I IUCRC at Indiana University: Center for Bioanalytic Metrology

生物分析计量中心（CBM）是圣母大学、印第安纳州大学和普渡大学之间的合作伙伴关系，通过与行业合作解决测量科学和技术领域当前、新兴和行业相关的挑战，提高美国的竞争力。该中心有两个主要目标：（1）提供一流的分子测量工具和专业知识，使强大的新的竞争前技术和能力的发展跨越制药，生物技术，食品/营养/农业，能源和分析仪器部门;和（2）作为一个试验场的新仪器应用到尖端的化学和生物化学问题。测量科学和相关仪器是美国经济的关键贡献者，从药物发现到材料制造，都在取得进步。通过将这些高科技领域的公司与主要的分析仪器制造商聚集在一起，CBM弥合了学术界和工业界合作产生的新想法的初步演示与能够推动技术发展的实用竞争前知识的交付之间的差距。同样重要的是，CBM为美国工业界提供了令人信服的机会，通过获得中心培训的学生的多样性和现有员工继续教育的机会来振兴人力资源。CBM致力于解决广泛定义的重要测量科学挑战。我们的一些成员主要对生物分析测量科学感兴趣，其他人则对与小分子药物或农用化学品有关的问题感兴趣，而其他人则主要对食品，石化产品或材料的分析感兴趣。CBM为这些成员提供以下方面的研究解决方案：（a）痕量生物标志物和杂质的微生物灵敏度分析;（B）大生物分子及其多分子复合物之间的区分;（c）以高通量和生产率减少体积/材料分析和实验;（d）稀有/极稀细胞/分子/外来体等的分析; (e)大规模并行的化学细胞术，遗传分析和面板筛选方法;（f）在线和近线原位测量;（g）现场使用点分析，伴随诊断和廉价测试;（h）人工智能驱动的仪器，反馈优化和无人驾驶仪器;以及（i）增强细胞，生物体和化学过程的成像。印第安纳州大学在微/纳米级分析分离和测量，气相离子的质谱和/或离子迁移率分析，多维数据的计算分析，基因组学，蛋白质组学，新催化剂和反应的组合分子生物学，生物分子的二维光谱表征，电化学分析和成像，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.The CBM is devoted to tackling important measurement science challenges, broadly defined. Some of our members are primarily interested in bioanalytical measurement science, others in problems relating to small molecule pharmaceuticals or agrochemicals, while still others are primarily interested in the analysis of foods, petrochemicals, or materials. The CBM serves these members with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and driverless instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Indiana University contributes distinct expertise in micro/nanoscale analytical separations and measurement, mass spectrometry and/or ion mobility analysis of gas phase ions, computational analysis of multidimensional data, genomics, proteomics, combinatorial molecular biology for new catalysts and reactions, two-dimensional spectroscopic characterization of biomolecules, electrochemical analysis and imaging, and design and construction of instrumentation and electronics to enable new methods of chemical analysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.