Surface Effects on Fluid Flows in 3D Printed Micro-channels: Computational Simulations with Empirical Validation

研究不同形状和粗糙度的微通道中的血液流动和血液驱动的细胞和颗粒运输对于制造和表征用于分离血液成分的许多医疗设备至关重要。本研究的目的是采用一个计算-实验相结合的框架来研究血液的流体动力学和血液流动驱动的运输。将采用增材制造技术来制造具有不同粗糙度的直的和螺旋的微通道。微通道横截面和表面粗糙度将使用microCT成像进行量化。将通过导入microCT成像数据来构建表示粗糙的直微通道和螺旋微通道的计算几何形状。在这个模拟几何的两相流体流动模型（血浆代表一个阶段和红细胞另一个）将被用来量化的血液运输作为一个功能的hematocrit.This奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

Investigating the flow of blood and blood-driven transport of cells and particles in microchannels of different shapes and degrees of roughness is critical for fabricating and characterizing a host of medical devices meant for separating blood components. The objective of this proposal is to employ a combined computational-experimental framework for studying the fluid dynamics of blood and blood flow driven transport.Additive manufacturing techniques will be employed to fabricate straight and spiral microchannels with varying degree of roughness. The microchannel cross-section and surface roughness will be quantified using microCT imaging. A computational geometry representing the rough straight and spiral microchannels will be constructed by importing the microCT imaging data. In this simulation geometry a two-phase fluid flow model (plasma representing one phase and red blood cells another) will be employed to quantify the blood transport as a function of hematocrit.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.