PFI-TT: Interactive Block Games for Routine Cognitive Assessment of Mild Cognitive Impairment and Alzheimer's Disease

这项创新-技术转化伙伴关系（PFI-TT）项目具有更广泛的影响和商业潜力，满足了社会对轻度认知障碍（MCI）和阿尔茨海默病（AD）常规认知评估的低成本、长期解决方案的迫切需求。在MCI阶段早期发现是延迟这种退行性疾病发作和减缓症状恶化的关键。该项目将重新发明一种新颖的、自动化的、基于游戏的技术，可用于对患阿尔茨海默病高风险的老年人进行常规认知评估。这种技术支持的方法将显著降低与认知评估相关的成本，并能够客观准确地测量一个人的认知状态，这将导致早期发现与MCI和AD相关的认知能力下降。该项目还为参与研究和研讨会活动的不同学生带来了独特而宝贵的学习和培训机会。拟议的应用研究将与研究生的培训和指导紧密结合，以成为未来技术创新和创业的领导者。拟议中的项目将开发一种新的技术平台，用于老年人的自动化、基于游戏的常规认知评估，并展示其商业潜力。这个创新的系统采用了一套高度仪器化的立方体与电脑游戏相结合。这些立方体具有可编程的视觉、听觉和触觉感官反馈机制，以及嵌入式运动传感器，通过互动游戏来评估用户的表现和行为。这些游戏将为目标人群量身定制，旨在捕捉工作记忆、空间推理、反应时间和手眼协调技能。游戏复杂度的综合计算度量将使系统能够根据用户的表现自动调整游戏难度。该系统不仅可以自动化管理和数据收集过程，还可以产生新的行为数据类型，如手部震颤、重复或过度活跃的动作以及操作速度。拟议的技术开发和评估将采用共同设计的方法，以便有效地解决用户特定的需求和技术改进，以实现潜在的商业化。与当地持续护理退休社区（CCRC）的合作将通过利用在合作CCRC中建立的生活实验室来简化和加速复杂的共同设计过程。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project addresses the urgent social need of a low-cost, long-term solution for routine cognitive assessment of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Early detection at the MCI stage is a key to delaying onset of this degenerative disease and slow worsening of the symptoms. This project will re-invent a novel, automated, game-based technology that can be used for routine cognitive assessment of older individuals who are at a high risk of developing AD. This technology-enabled method will significantly lower the cost associated with cognitive assessment and enable objective and accurate measurements of one's cognitive status, which will lead to early detection of cognitive declines associated with MCI and AD. This project also brings unique and valuable learning and training opportunities for the diverse students participating in the research and workshop activities. The proposed applied research will be tightly integrated with the training and mentoring of graduate students to become future leaders in technology innovation and entrepreneurship.The proposed project will develop a novel technology platform for automated, play-based routine cognitive assessment in older adults and demonstrate its commercial potential. This innovative system employs a set of highly instrumented cubes interfacing with computerized games. The cubes feature programmable visual, auditory, and tactile sensory feedback mechanisms and embedded motion sensors for user performance and behavior assessment via interactive play. The games will be designed to capture working memory, spatial reasoning, response time, and hand-eye coordination skills tailored for the target population. The integrated computational measures of play complexity will enable the system to automatic adjust the game difficulty based on the user performance. The system will not only automate the administration and data collection process, but also produce new types of behavioral data, such as hand tremor, repetitive or hyperactive motions, and manipulation speed. The proposed technology development and evaluation will take the co-design approach in order to effectively address user-specific requirements and technical improvements for potential commercialization. A partnership with a local continuing care retirement community (CCRC) will streamline and accelerate the complex co-design process via utilizing the living lab established in the partnering CCRC.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.