How to build the head: A molecular mechanistic insight

该项目旨在深入了解基因调控网络的功能输出以及对头部形成至关重要的分子决定因素。全基因组测序技术被用来鉴定Lhx1调控的基因集合。通过生物信息学分析和系统生物学方法的结合，该项目旨在建立头部发育相互作用基因网络的模型，并对该网络的选定组件的功能进行分析，以完善其架构并定义网络的动态。这些知识可能会提高我们对支持主要身体部位形式自然发生变化的分子机制的理解，以及基因和信号如何合作构建胚胎。

This project aims to gain an insight into the functional output of the gene regulatory network and the molecular determinants that are critical for the formation of the head. Genome-wide sequencing technologies are employed to identify the ensemble of genes that are regulated by Lhx1. By a combination of bioinformatics analysis and a system biology approach, the project aims to build a model of the network of the interacting genes for head development, and to characterise the function of selected components of this network to refine its architecture and define the dynamics of the network. The knowledge may improve our understanding of the molecular mechanism underpinning the naturally-occurring variation in the forms of major body parts, and of how genes and signals work cooperatively to build an embryo.