Research Infrastructure: Peromyscus Genetic Stock Center Support

鹿鼠（鹿鼠属）是北美最丰富的啮齿动物，被世界各地的研究人员广泛用于生态学和进化、遗传学、生理学、公共卫生和传染病等学科的研究。除了学术调查人员，Peromyscus的用户还包括美国其他联邦机构和私人实体。南卡罗来纳大学的Peromyscus遗传资源中心（PGSC）维护并分配了5种不同的Peromyscus物种。该奖项的支持将有助于PGSC的不间断运行。PGCS的任务是维持各种近亲繁殖，遗传多样化的鹿鼠（Peromyscus属）的殖民地，并将它们分发给美国和世界各地的研究人员。目前维持着6个不同的封闭菌落，涉及5种Peromyscus: P. maniculatus（2个菌落）、P. polionotus、P. eremicus、P. californicus和P. leucopus。对于在PGSC中产生的所有动物，自最初建立菌落以来的系谱数据可供外部用户使用。获得纯种动物，包括来自“参考”野生型种群的动物，对研究的可重复性具有特别重要的意义。此外，可以根据要求执行特定的小规模实验任务，并作为合同研究操作提供（例如，DNA取样、组织学分析、特殊饮食、卵巢切除术或输精管切除术）。PGSC还作为高齿蚌相关研究的焦点，积累和传播信息给感兴趣的社区，并为访问研究者提供关于高齿蚌处理和群体维护的培训。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Deer mice (Genus Peromyscus) are the most abundant rodents in North America and are used extensively by investigators all over the world for research in disciplines ranging from ecology and evolution, to genetics, physiology, public health and infectious diseases. Besides academic investigators, Peromyscus users also include other federal agencies in the U.S. and private entities. The Peromyscus Genetic Stock Center (PGSC) of the University of South Carolina maintains and distributes animals of 5 different species of Peromyscus. Support from this award will assist in the uninterrupted operation of the PGSC.The mission of the PGCS is to maintain colonies of various species of outbred, genetically diverse deer mice (genus Peromyscus) and distribute them to investigators in the US and all over the world. Six different closed colonies are currently maintained, involving 5 Peromyscus species: P. maniculatus (2 colonies), P. polionotus, P. eremicus, P. californicus, and P. leucopus. For all animals generated in the PGSC, pedigree data since the original establishment of the colonies are available to external users. The availability of pedigreed animals, including animals from "reference" wild type populations, is of particular significance for research reproducibility. In addition, specific small-scale experimental tasks can be performed upon request and are provided as contract research operations (e.g., DNA sampling, histologic analyses, special diets, ovariectomy, or vasectomy procedures). The PGSC also serves as a focal point for Peromyscus-associated research to accumulates and disseminate information to the communities of interest and provides training for visiting investigators on Peromyscus handling and colony maintenance.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.