PDB Management by The Research Collaboratory for Structural Bioinformatics

该奖项将为结构生物信息学研究合作实验室（RCSB）蛋白质数据库（PDB）提供持续支持。RCSB PDB与社区利益相关者合作，免费保存并向全球数百万PDB数据消费者提供蛋白质数据库（以下简称PDB或存档）中存档的经过严格验证、专业生物处理的三维（3D）生物结构信息，并且没有使用限制。通过RCSB PDB门户网站对这些实验确定的蛋白质和核酸结构进行探索是通过最先进的数据分析，可视化和下载工具实现的。RCSB PDB确保结构生物学数据是可查找-可解释-可互操作-可重用（FAIR）的。对PDB数据和RCSB PDB服务的访问将继续推动专利申请、药物发现和开发、从农业到动物学等科学学科的创新研究出版，以及导致发现和开发改变生活的生物制药产品和成立新的美国公司的创新。开放PDB数据和RCSB.org工具将有助于研究人员抗击COVID-19等流行病和其他新兴传染病。RCSB PDB培训，推广和教育工作利用PDB数据和RCSB PDB工作人员的专业知识来开发材料，帮助学生和研究人员学习如何将3D生物结构与知识联系起来。在线培训资源和面对面的活动将使高年级本科生，研究生，博士后和研究人员的教育，政府实验室和工业，并帮助建立一个强大的STEM劳动力。RCSB PDB研究为重点的门户网站将提供开放访问200，000实验确定的PDB结构，1，000，000计算结构模型，和越来越多的集成/混合结构，使其成为唯一的一站式商店，提供公共领域的3D结构信息，跨越从小分子配体到小蛋白质和核酸到巨大的大分子机器的长度尺度。RCSB蛋白质数据库（PDB）提案的智力价值反映在该组织长期以来在维持开放获取的全球数据资源方面的科学和技术领导地位，该数据资源是生物学和医学研究和教育的核心，通过在生物功能，生化途径细胞过程，疾病状态，和分子进化。RCSB PDB网站支持研究（RCSB.org）和培训（PDB-101网站），促进对基础生物学，生物医学和原子水平三维能量的理解。RCSB PDB使命的高效、持续履行在很大程度上取决于与PDB存储者和数据消费者、化学和生物数据资源、生物分子数据管理的国际领导者、科学和专业协会以及对生命科学、化学、计算科学、医学科学、药物发现、生物技术和教育感兴趣的利益相关者团体的广泛合作和伙伴关系。RCSB PDB与这个充满活力和不断发展的合作者网络一起，致力于提供数据和相关的网络基础设施服务，并为美国和地球仪的不同用户社区提供重要价值。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Support from this award will provide ongoing support for the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB). The RCSB PDB works with community stakeholders to preserve and deliver rigorously validated, expertly biocurated three-dimensional (3D) biostructure information archived in the Protein Data Bank (hereafter PDB or the archive) to millions of PDB Data Consumers worldwide at no charge and with no limitations on usage. Exploration of these experimentally-determined structures of proteins and nucleic acids via RCSB PDB web portals is enabled by state-of-the-art data analysis, visualization, and download tools. RCSB PDB ensures that structural biology data are Findable-Accessible-Interoperable-Reusable (FAIR). Access to PDB data and RCSB PDB Services will continue to drive patent applications, drug discovery and development, publication of innovative research in scientific disciplines ranging from Agriculture to Zoology, and innovations leading to discovery and development of life-changing biopharmaceutical products and formation of new US companies. Open access to PDB data and RCSB.org tools will help researchers in the fight against pandemics such as COVID-19 and other emerging infectious diseases. RCSB PDB training, outreach, and education efforts leverage PDB data and RCSB PDB staff expertise to develop materials that help students and researchers learn how to connect 3D biostructures to knowledge. Online Training resources and in-person events will enable education of senior undergraduates, graduate students, postdocs, and researchers in academe, government laboratories, and industry, and help to build a robust STEM workforce.The RCSB PDB research-focused web portal will provide open access to 200,000 experimentally-determined PDB structures, 1,000,000 Computed Structure Models, and a growing number of Integrative/Hybrid structures, making it the only one-stop shop that delivers public domain 3D structure information traversing length scales ranging from small-molecule ligands to small proteins and nucleic acids to enormous macromolecular machines. The intellectual merit of the RCSB Protein Data Bank (PDB) proposal is reflected in the organization’s long history of scientific and technical leadership in sustaining an open-access global data resource that is central to research and education in biology and medicine, by curating, integrating, and disseminating 3D biostructure information in the context of biological function, biochemical pathways cellular processes, disease states, and molecular evolution. RCSB PDB websites supporting research (RCSB.org) and training (PDB-101 website) foster understanding of fundamental biology, biomedicine, and energy in three-dimensions at the atomic level. Efficient, ongoing fulfillment of the RCSB PDB mission has depended critically on extensive collaborations and partnerships with PDB Depositors and Data Consumers, chemical and biological data resources, international leaders in biomolecular data curation, scientific and professional societies, and stakeholder groups with interests in the life sciences, chemistry, computational sciences, medical sciences, drug discovery, biotechnology, and education. Together with this dynamic and evolving network of collaborators, RCSB PDB is committed to delivering data and related cyberinfrastructure services, and providing significant value to diverse user communities in the US and around the globe.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.