Gene-brain pathways in emotional brain stability and instability

情绪不稳定是主要精神疾病的一个特征。识别易受情绪不稳定影响的个体的能力对于限制这些疾病的疾病负担至关重要。精神疾病使澳大利亚经济每年损失约14.9澳元，到2020年，抑郁症将成为疾病负担的第二大贡献者。该项目将为基因-大脑-行为标记的组合提供第一个证据，这些标记最能捕捉情绪不稳定性与弹性。这一证据基础对于开发早期干预的新工具和战略以及最终预防这些心理健康状况至关重要。

Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combination of gene-brain-behaviour markers which best capture emotional instability versus resilience. This evidence base will be crucial to developing new tools and strategies for early intervention, and ultimately prevention, for these conditions of mental health.