PFI-TT: Expanding the Market Share of Domestically Produced Primary Phosphines

这一创新-技术转化伙伴关系(PFI-TT)项目的更广泛影响/商业潜力是对多样化的化学品原料所产生的经济发展的支持。伯膦是一种含有单一有机取代基的有机磷化合物，是重要的化学前体。它们的使用可以使农业、生物医学、材料科学和消费品受益，因为它们支持高效地制备各种有益于社会的已知、有用的产品，并帮助开发新产品。目前生产初级磷化氢的技术是高度浪费和危险的。该项目的技术为这些产品提供了更高的安全性和更少的废物，可以扩大国内的化工生产。该项目利用催化作用，支持这个环境友好、价值数十亿美元的行业进一步发展。该项目团队在让边缘身份的个人参与科学研究以扩大未来STEM劳动力方面有着很强的记录。这些努力将继续服务于国家和州的劳动力发展目标。此外，该项目的一部分将帮助创业教育的长期发展，以培养地区学生，他们将为未来的技术转让和将科学转化为市场就绪的产品做好更好的准备。拟议中的项目寻求将NSF资助的发现转化为可行的市场技术。为了实现这一目标，将使用Lewis酸催化制备伯膦。路易斯酸催化已成为人们极感兴趣的话题，包括获得2022年诺贝尔化学奖的认可。这些尖端发现的应用将解决初级磷化氢合成中的关键挑战，即摆脱以金属为基础的危险还原剂。该项目的目标包括扩大可用这种方法制备的初级磷化氢，探索包括固态催化剂在内的替代催化剂，并为扩大规模生产做准备。应用研究计划直接涉及路易斯酸催化在制备附加值产品中的更实际应用。该项目旨在支持市场上的新技术和新产品。为了实现这些目标，路易斯酸催化制备商品化学品的机会将通过更好地了解其反应性而扩大，特别是在规模上。利用替代路易斯酸的能力也将通过该项目实现，并将了解磷化学的其他方面。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is the support for the economic development resulting from a diversified chemical feedstock. Primary phosphines, organophosphorus compounds containing a single organic substituent, are important chemical precursors. Their use can benefit agriculture, biomedicine, materials science, and consumer goods by supporting efficient preparation of a wide range of known, useful products that benefit society as well as to help develop new products. Current technology that produces primary phosphines is highly wasteful and hazardous. This project’s technology provides these products with increased safety and reduced waste, which can expand domestic chemical production. This project leverages catalysis and supports further growth of this environmentally friendly, multi-billion-dollar industry. The project team has a strong record of involving individuals from marginalized identities in science to expand the future STEM workforce. Such efforts will continue to serve national and state workforce development goals. Additionally, part of this project will aid in the long-term development of entrepreneurship education to yield regional students who will be better prepared for technology transfer and conversion of science to market-ready products in the future. The proposed project seeks to transition an NSF-funded discovery to a viable marketplace technology. To meet this goal, Lewis acid catalysis will be used to prepare primary phosphines. Lewis acid catalysis has become a topic of tremendous interest including recognition by the 2022 Nobel Prize in Chemistry. Application of these cutting-edge discoveries will address the key challenge in primary phosphine synthesis, which is to move away from hazardous metal-based reducing agents. Goals of the project include expansion of the primary phosphines that can be prepared by this method, exploration of alternative catalysts including solid state catalysts, and preparations for growth to pilot scale production. The applied research plan directly addresses the more practical utilization of Lewis acid catalysis in the preparation of value-added products. The project aims to support new technology and new products in the marketplace. In meeting these goals, opportunities for Lewis acid catalysis in the preparation of commodity chemicals will be expanded through a greater understanding of their reactivity, especially at scale. The ability to utilize alternative Lewis acids would also be realized through this project, and additional aspects of phosphorus chemistry will be understood.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.