Studies of the Dynamic Language of Bio-Molecular Communication and Signalling

为了正常的生物功能，细胞必须对大量的外部信号进行解释和响应。这些反应必须仔细调节和协调，否则病理状态就会发展，如果不加以纠正，就会导致不受控制的增殖或细胞死亡。这个项目研究细胞传递信号的机制。蛋白质通过改变其功能结构域之间的相互作用来完成这种交流，有效地创建了一种构象语言。这种语言的知识将通过它对理解疾病状态的分子病理学的贡献来影响生物医学，并通过提高我们使用生物过程进行应用的能力来影响生物技术。

For normal biological function, a multitude of external signals must be interpreted and responded to by cells. The responses must be carefully regulated and coordinated, or else pathological conditions will develop and, if not corrected, lead to uncontrolled proliferation or cell death. This project studies the mechanisms by which cells transmit signals. Proteins accomplish this communication by modifying the interactions among their functional domains, effectively creating a conformational language. Knowledge of this language will impact biomedicine through its contributions to understanding the molecular pathology of diseased states, and biotechnology by enhancing our ability to use biological processes for applications.