Effects of magnetic and electric fields, mechanical stress on the conformational state and release behavior of the composite gels with embedded colloid particles

该项目的目标是通过(微型)乳液聚合、溶胶凝胶法以及在可聚合水凝胶单体和两亲分子存在下依靠分子前体的水解和缩合反应进行协同自组装等先进技术相结合，合成由A/-异丙基丙烯酰胺、疏水成分(药物/染料)和纳米二氧化硅组成的新型相分离水凝胶。将采用两种不同的战略：(A)水凝胶，其中包含嵌入的不溶于水的有机和/或无机物质的窄分布纳米液滴，以及(B)水凝胶作为连续无机凝胶相中的(纳米)液滴。除了合成方面，还将研究复合凝胶的体积相变，以及它们的弹性，并结合凝胶相中乳滴的显微和X射线研究。研究复合凝胶对一些典型药物化合物以及表面活性剂和染料的吸收-释放性能，并与它们的结构和化学组成相关联。

The aim of the project is the synthesis of novel phase separated hydrogels composed of A/-isopropylacrylamide, hydrophobic components (drugs/dyes) and nanostructured silica by a combination of advanced techniques such as (mini)emulsion polymerization, sol-gel processing, and cooperative self-assembly relying on hydrolysis and condensation reactions of molecular precursors in the presence of polymerizable hydrogel monomers and amphiphiles. Two different strategies will be followed: (a) hydrogels containing embedded narrowly distributed nanodroplets of water-insoluble organic and/or inorganic substances, and (b) hydrogels as (nano)droplets in a continuous inorganic gel phase. In addition to the synthetic aspects, the volume phase transitions of the composite gels will be studied, in addition to their elasticity combined with microscopic and X-ray based investigations of the emulsion droplets in the gel phase. Absorption - release properties of the composite gels will be investigated for some typical drug compounds as well as surfactants and dyes and correlated to their structure and chemical composition.