Population genetics of hematopoietic neoplasms (A16)

肿瘤的发展可以被认为是一个进化过程。从这个角度来看，化疗会产生进化压力，而耐药性的获得可以理解为肿瘤的进化适应。我们开发了理论工具来分析造血肿瘤的这些进化过程，包括遗传和表观遗传突变的作用。为此，我们采用了进化生物学，特别是种群遗传学的随机建模和数据分析方法。

The development of a tumor can be considered as an evolutionary process. From this point of view, e.g. chemotherapy generates an evolutionary pressure, and the gain of resistance can be understood as evolutionary adaptation in the tumor. We develop theoretical tools to analyze these evolutionary processes in hematopoietic neoplasms, including the role of genetic and epigenetic mutation. For this we adopt approaches of stochastic modeling and of data analysis from evolutionary biology and in particular from population genetics.