Design, Synthesis and Biological Evaluation of Rotavirus Inhibitors

轮状病毒在世界范围内造成重大生命损失，特别是在5岁以下儿童中。每年有400,000多名5岁以下儿童死于轮状病毒感染。澳大利亚记录了每年有10,000多人因轮状病毒感染而住院。该项目旨在利用基于结构的药物设计技术，开发一种轮状病毒蛋白质的抑制剂，这种蛋白质在其生命周期中是必不可少的。这些抑制剂可能导致开发出治疗轮状病毒感染的有用药物，并可能减少这种致命病毒造成的重大生命损失。

Rotavirus causes, particularly in children under 5 years of age, significant loss of life worldwide. Over 400,000 children under 5 years of age per annum die as a result of rotavirus infection. Australia records over 10,000 hospitalisations per annum due to rotavirus infection. This project aims, using structure-based drug design techniques, to develop inhibitors of a rotavirus protein that is essential in its lifecycle. These inhibitors may lead to the development of useful drugs to treat rotavirus infection and may reduce significant loss of life caused by this deadly virus.