若年期の摂食制限の記憶がもつ成年期の摂食行動における役割

在过去的一个财政年度，我们在理解从海马下托到下丘脑弓状核的神经回路方面取得了重大进展。利用CRE重组酶和FLP重组酶的病毒组合，我们观察到在下托中的标记细胞。我们还采用了基于病毒的操作方法来研究这个回路在进食和学习组件中的作用。同时，行为范式也证实了动物的内部状态（饥饿或饱足）可能是适应行为的一个背景。这些发现对我们理解参与进食和学习的神经回路具有重要意义，并可能为相关疾病的靶向治疗铺平道路。

Over the last fiscal year, we have made significant progress in our understanding of the neural circuit from subiculum in hippocampus to arcuate nucleus in hypothalamus. Using a virus combination of CRE recombinase and FLP recombinase, we observed the labelling cells in the subiculum. We have also employed viral-based manipulation methods to investigate the role of this circuit in both feeding and learning components. Meanwhile, the behavior paradigm also confirmed that the internal state of animals (hunger or satiety) could be a context for adaptive behaviors. These findings have important implications for our understanding of neural circuits involved in feeding and learning and may pave the way for targeted therapies for related disorders.