An atypical microtubule generation mechanism for neurons drives dendrite and axon development and regeneration

在神经系统疾病中，微管调节因子突变的发生率很高；因此，了解产生和组织神经元mt细胞骨架的过程对科学界和医学界具有很高的价值。微管在神经元发育和成熟神经元功能中起着至关重要的作用。首先，为了生成复杂的分枝树突和轴突，有必要构建微管细胞骨架。其次，这些微管是马达传递受体、神经递质和细胞器的路径。第三，在成熟神经元中，微管也与突触可塑性有关。尽管最近的研究显示了微管调节在突触功能中的重要性，但微管动力学的变化如何以及是否促成神经系统疾病的诱导尚不清楚。这个项目发现了通过微管塑造神经系统组织的新分子机制。神经元中存在哪些进化上保守的特殊微管生成途径？它们是如何被用来控制神经元连接模式的发展的？在受伤后如何重新利用它们进行恢复？

There is a high prevalence of mutations in microtubule regulators in neurological disorders; therefore, understanding the processes that generate and organize the cytoskeleton of neuronal MTs is a matter of high value for the scientific and medical communities. microtubules play critical roles in neuron development and then in mature neuron function. First, to generate complex branching dendrites and axons, it is necessary to build a cytoskeleton of microtubules. Second, these microtubules are tracks along which motors deliver receptors, neurotransmitters, and organelles. Third, in the mature neuron, microtubules also play roles associated with synaptic plasticity. Although recent studies show the importance of microtubule regulation in synaptic function, it is still unclear how and whether changes in microtubule dynamics precipitate the induction of neurological diseases. This project discovers new molecular mechanisms that shape nervous system organization through microtubules.What evolutionarily conserved specialized microtubule generation pathways exist in neurons?How are they used to control the development of neuronal wiring patterns?How are they reutilized for recovery after injury?