Conservation and diversity in transcriptional regulation of developmental processes in crop and model plant species (CISCODE) (ERA-PG 024)

该项目将在比较的背景下使用基因组学技术，以利用物种多样性中存在的信息，填补我们对模式植物和作物的理解中的空白。我们将专注于一个基本的，经济上重要的和实验上易于处理的生物系统，植物繁殖，并使用基因组和后基因组工具来模拟和操纵生殖过程中心的调控网络。使用比较的方法，我们的目标是了解非编码DNA区域的进化变异如何导致（作物）物种生殖过程的变异。为了从广泛的比较分析中获得最大的利益，我们将重点关注一组关键的遗传相互作用，其特征在于在参考物种拟南芥中的深度。我们这个项目的最终目的是实现控制植物繁殖的顺式调控元件的理解，了解这个网络中的进化变异，并从这些信息中受益，以可预测地操纵系统。

This project will use genomics technologies in a comparative context to harness the information present in the diversity of species to fill in the gaps in our understanding of model and crop plants. We will focus on a fundamental, economically important and experimentally tractable biological system, plant reproduction, and use genomic and post-genomic tools to model and manipulate the regulatory network at the centre of the reproductive process. Using a comparative approach, we aim to understand how evolutionary variation in non-coding DNA regions has led to variation in reproductive processes in (crop) species. To derive maximum benefit from a broad comparative analysis, we will focus on a key set of genetic interactions characterised in depth in the reference species, Arabidopsis. Our final aim of this project is to achieve an understanding of the cis-regulatory elements controlling reproduction in plants, to understand the evolutionary variation in this network and to benefit from this information to predictably manipulate the system.