Systemic Inflammatory Response Indication Observer (SIRIO)

天狼星项目(全身炎症反应指示观察者)的目标是开发一种混合型摄像机监测系统，用于早期检测早产儿的脓毒症。Sirio将基于相机的生命参数监测系统、光体积图成像和红外成像融合为基于相机的混合成像技术，用于检测新生儿的生命状态。这两种方法都是非接触式获取生命参数的新方法。因此，它们可以在现有基础设施之外运行。另一个优点是与患者没有直接接触，因此早产儿的皮肤不会受到伤害。一般来说，患者不会受到任何额外的压力，也不会有感染的风险(由测量技术引起)。这种混合测量技术允许对生命体征进行非接触式检测，包括：1)皮肤血液循环、2)心跳和呼吸频率及其变异性、3)皮肤灌注(中央和外周)、4)皮肤颜色和5)身体活动。这些败血症特征将被融合到评分参数中。该评分参数将从儿科早期预警评分(PEWS)中得出，该评分已在临床常规中建立。如果出现最初的败血症症状，就会触发警报，这样就可以根据标准的治疗指南启动下一个手动步骤，而不会损失时间：确认诊断，例如检查毛细血管形成时间，确定血培养和后续治疗。该项目设想实施混合监测概念和开发信号处理例程，为主治临床工作人员提供实时决策支持系统--在新生儿站现有基础设施的基础上，悄悄地增加。为了这个项目，当地伦理委员会批准了一项针对20名早产儿的临床人体研究。在临床前试验的基础上，本研究将证明该系统的可行性。

The aim of the SIRIO project (Systemic Inflammatory Response Indication Observer) is the development of a hybrid camera monitoring system for an early detection of sepsis in premature infants. SIRIO fuses the camera-based vitalparamater monitoring systems Photoplethysmography Imaging and Infrared Imaging into a camera-based Hybrid Imaging technology for the vital state detection in neonates. Both methods are novel approaches to obtain vital parameters contactless. Hence, they can operate in addition to the existing infrastructure. A further advantage is that there is no direct contact with the patient so that the premature infant skin is not harmed. In general, the patient is not subjected to any additional stress and there is no risk of infection (caused by the measurement technique). This hybrid measuring technique allows the contactless detection of vital signs, including: 1) cutaneous blood circulation, 2) heart and respiratory rate as well as their variability, 3) the skin perfusion (central and peripheral), 4) skin coloring, and 5) physical activity.From these measured parameters, first septic indications will be automatically recognized. These septic features will be fused into a scoring parameter. This scoring parameter will be derived from the Pediatric Early Warning Score (PEWS), which is already established in the clinical routine. In case of first septic signs, an alarm is triggered, so that the next manual steps can be initiated according to the standard treatment guidelines without time loss: confirmation of the diagnosis, e.g. by checking the capillarization time, determination of blood culture and subsequent therapy.The project envisages the implementation of the hybrid monitoring concept and the development of signal processing routines, which provide a real-time decision support system for the attending clinical staff - unobtrusively and additively to the existing infrastructure at the neonatology station.For this project, the local Ethics Committee authorized a clinical human study with 20 preterm infants. Based on preclinical tests, the feasibility of this system will be proved within this study.