Novel vitamin E analogues disrupt autocrine signalling and angiogenesis: Mechanistic studies and relevance to cancer management

在澳大利亚，乳腺癌和间皮瘤癌症是一个严重的问题，许多患者由于缺乏适当的治疗而死亡。我们相信，维生素E类似物，对癌细胞有效的选择性药物，有望成为未来治疗这两种病理的药物。维生素E类似物通过几种机制起作用，包括对癌细胞的毒性作用，以及对肿瘤有效发展所必需的细胞，如恶性血管细胞的毒性作用。该项目的成果将用于准备这些极具前景的药物的临床试验。

Breast and mesothelioma cancers present a severe problem in Australia and many patients succumb due to lack of appropriate treatment. We believe that vitamin E analogues, selective drugs efficient against cancer cells, hold a promise as future drugs against these two pathologies. Vitamin E analogues act by several mechanisms, including toxic effect on the cancer cells and also on cells that are necessary for efficient progression of tumours, such as cells of the malignant blood vessels. Results of this project will be used to prepare clinical testing of these highly promising drugs.