Central service project - Analysis and Synthesis of sphingolipids

中心服务项目将侧重于分析和合成鞘脂，并将为优先计划的所有参与者提供服务。许多复杂的鞘脂，以及简单的鞘氨醇碱和衍生物，是高度生物活性的细胞外和细胞内的生长，分化，迁移，存活，衰老和众多的细胞应激反应的调节剂。鞘脂代谢的失调通常与诸如炎症、癌症、心血管病症、糖尿病或神经变性的疾病相关。出于这个原因，重要的是要量化所有这些化合物，或至少是一个关键子集的所有成员。因此，中央服务项目有两个目标：（i）它将提供复杂鞘脂的鉴定和定量。(ii)由于鞘脂具有很好的治疗潜力，该服务将合成商业上不可用的必需鞘脂，或产生大量实验程序所需的特定鞘脂。这些目标需要训练有素的人员、丰富的经验和昂贵的设备;因此，这些目标将在中央服务项目中实现。

The Central Service Project will focus on the analysis and synthesis of sphingolipids and will provide services for all participants in the priority program. Many complex sphingolipids, as well as simple sphingoid bases and derivatives, are highly bioactive as extracellular and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. The dysregulation of sphingolipid metabolism is often associated with diseases such as inflammation, cancer, cardiovascular disorders, diabetes, or neurodegeneration. For this reason it is important to quantify all of these compounds, or at least all members of a crucial subset. Thus, the Central Service Project has two aims: (i) It will provide identification and quantification of complex sphingolipids. (ii) Because of the promising therapeutic potential of sphingolipids, the service will synthesize essential sphingolipids that are not commercially available or will produce large amounts of specific sphingolipids that are necessary for experimental procedures. These aims require trained personnel, extensive experience, and expensive equipment; thus, these aims will be performed in a Central Service Project.