Basic study ot the implantable artificial kidney
Basic study ot the implantable artificial kidney
批准号:
24650251
负责人:
ABE Yusuke
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
血液透析已经成为抢救严重肾衰竭患者的一种既定疗法。但是,它限制了患者的时间,增加了医疗费用。完全植入体内的人工肾的研制有望突破这一现状。在这项研究中,连续血液水力旋流器离心分离方法的发展,植入式人工肾提出。我们开发了三种类型的水力旋流器来研究血液浓度。结果,尽管在红细胞(RBC)浓度方面没有观察到显著差异,但在水力旋流器的中心观察到红色柱。该柱表明,旋流器中的二次涡是红细胞聚集的主要原因。 进一步的研究,观察粒子图像测速仪和高速摄像机是必要的,以证明在红细胞中的浓度的可能性。
英文摘要
Hemodialysis has been already an established therapy to rescue patients with severe renal failure. However, it restricts time of patients and increases medical expenses. Development of the artificial kidney for completely embedding in the body is expected to break through the present status. In this study, a continuous blood hydrocyclone centrifugal separation method for the development of an implantable artificial kidney was proposed. We developed three types of hydrocyclones to investigate concentration of blood. As a result, despite that no significant difference was seen in concentration of red blood cell (RBC), a red pillar was observed in the center of the hydrocyclone. This pillar was suggested that the RBC was accumulated by the secondary vortex in the hydrocyclone. Further study to observe with a particle image velocimetry and the high speed video camera is necessary to demonstrate a possibility of concentration in the RBC.
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