Effects of immune cells on inflammatory responses and oxidative stress in the exercise-induced muscle damage

虽然运动会导致肌肉损伤，但其潜在机制尚未完全了解。本研究应用中性粒细胞迁移抑制模型和巨噬细胞耗竭模型研究了中性粒细胞和巨噬细胞在小鼠力竭运动性急性肌肉损伤中的作用。应用抗中性粒细胞抗体可抑制腓肠肌中Ly-6 G阳性细胞（中性粒细胞）的浸润，应用氯膦酸盐脂质体可减少F4/80阳性细胞（巨噬细胞）的浸润及相关炎症反应。因此，中性粒细胞和巨噬细胞参与了运动性肌肉损伤。

Although exercise induces muscle damage, the underlying mechanisms are not fully understand. The present study examined the involvement of neutrophils and macrophages in the exhaustive exercise-induced acute muscle damage in mice by application of the inhibitory neutrophil migration model and macrophage depletion model. The administlation of anti-neutrophil antibody inhibited the infiltration of Ly-6G positive cells (neutrophils) in the gastrocnemius, and the administration of clodronate liposome reduced the infiltration of F4/80 positive cells (macrophages) and related inflammatory reactions. Therefore, it was demonstrated that neutrophils and macrophages are involved in the exercise-induced muscle damage.