Development of Rotaxane-type Supramolecular Complexes Whose Ring Moves Upon Phosphorylation and Dephosphorylatoin

分子马达如ATP合成酶是利用ATP的化学结合能的所谓“分子马达”。 本项目的目的是设计和合成人工超分子复合物，通过酶促磷酸化和去磷酸化反应改变其结构。 我们设计了轮烷类超分子复合物，其包含大环部分（环糊精（CyD））和穿过CyD环的轴部分。 在这项工作中，我们成功地合成了轮烷分子，它包含一个偶氮苯单元作为“站“在轴的中心和两个锌2 +-cyclen配合物单元作为“站2”在轴的边缘。

Molecular motors such as ATP synthetase are so-called "molecular motors" that utilize chemical bonding energy of ATP. The purpose of this project is to design and synthesize artificial supramolecular complexes, the structure of which are altered by enzymatic phosphorylation and dephosphorylation reactions. We have designed the rotaxane-like supramoleculer complexes that contain a macrocycle part (cyclodextrin (CyD)) and an axis part that is threaded through a CyD ring. In this work, we have succeed in the synthesis of the rotaxane molecule that contains an azobenzene unit as "Station " at the center of the axis and two Zn2+-cyclen complex units as "Station 2" at the edge of the axis.