Identification of cytotoxic T lymphocyte responses to lipopeptides in human immunodeficiency virus-infected patients.

最近在艾滋病的猴子模型中发现了一种新的宿主防御途径，在这种途径中，脂肽特异性的细胞毒性T淋巴细胞扩张并与感染作斗争。然而，这种T细胞反应是否可能存在于人类中仍有待确定。在这项研究中，我们首次发现在部分人类免疫缺陷病毒感染患者的循环中存在脂肽特异性T细胞，能够产生主要的宿主保护因子之一-干扰素-γ。

A new pathway for host defense has recently been identified in the monkey model of AIDS, in which lipopeptide-specific cytotoxic T lymphocytes expand and combat against infection. However, it remains to be determined whether such T cell responses may exist in humans. In this study, we found for the first time that lipopeptide-specific T cells existed in the circulation of a fraction of human immunodeficiency virus-infected patients, capable of producing interferon-gamma, one of the major host-protective factors.