Challenge for SHED-based Hematopoietic Regeneration

在人脱落乳牙干细胞上表达了促红细胞生成素受体（EPO）。epo刺激的SHED不调节Stat5磷酸化。在免疫功能低下小鼠体内皮下植入羟基磷灰石载体后，epo刺激的SHED比未刺激的SHED能增加造血壁龛的形成。在增加的造血生态位中，免疫荧光和流式细胞术分析发现造血细胞。综上所述，这些数据表明EPO能够通过SHED诱导造血能力。

Erythropoietin (EPO) Receptor was expressed on stem cells from human exfoliated deciduous teeth (SHED). EPO-stimutated SHED unregulated Stat5 phospholiration. EPO-stimulated SHED were capable of increasing the formation of hematopietic niches compared to non-stimulated SHED when SHED were subcutanously transplanted with hydroxyapatite carriers into immunocompromised mice. In the increase hematopoietic niche, hematopoietic cells were found by immunofluorescent and flow cytometric analyses. Taken together, these data suggested that EPO is able to induce the capacity of hematopoiesis through SHED.