Thermosensitive particles which release anticancer agent by applying magnetic field

我们开发了一种利用热敏铁磁粒子(FMP)进行磁感应加温的方法，该粒子具有足够低的居里温度(TC)，以调节自动温度控制。在这项工作中，我们评估了我们最初的热疗系统与纳米凝胶颗粒的抗癌药物输送相结合的体外效果。合成了一种基于N-异丙基丙烯酰胺(NIPAM)的纳米凝胶，对其进行了表征，并负载了甲氨蝶呤(MTX)。结果表明，随着温度的升高，热敏粒子的直径减小，MTX被显著释放。MTX联合我们原有的热疗系统抑制了培养的癌细胞的增殖，需要进一步的研究，包括体内实验，以使其成为肿瘤热化疗的理想候选者。

We have developed a method of magnetically induced hyperthermia using thermosensitive ferromagnetic particles (FMPs) with low Curie temperature (Tc) enough to mediate automatic temperature control. In this work, we evaluated the effect of our original hyperthermia system combined with the delivery of anticancer drug from nanogel particles in vitro. A nanogel based on polymerised N-isopropylacrylamide (NIPAM) was synthesized, characterized and loaded with methotrexate (MTX). The result was that diameter of thermosensitive particles reduced dependent on increasing temperature, and MTX was released significantly. The proliferation of cultured cancer cells was inhibited by MTX combined with our original hyperthermia system.Further investigation, including in vivo experiment, was needed to making them ideal candidates for cancer thermo-chemotherapy.