Development of novel rice blast control system, which suppresses mutations in the pathogen

稻瘟病是水稻上最重要的病害。水稻稻瘟病防治中的一大难题是病原菌的突变，使病原菌能够克服稻瘟病抗性。稻瘟病菌的突变大多是通过DNA重组发生的。本研究旨在通过对稻瘟病病原菌DNA重组蛋白的研究，开发一种新的抑制病原菌突变的防治策略。研究结果表明，DNA重组对病原菌的致病起着非常重要的作用。DNA重组蛋白作为一种复合体将成为控制疾病和抑制突变的靶点。在这项研究中，我们还开发了一个蛋白质相互作用抑制剂的筛选系统。

Rice blast is the most important disease of rice. One of the big problem in rice blast control is the mutation of pathogen that enables pathogens to overcome rice blast resistance. Mutations in rice blast fungus is mostly occur through DNA recombinations. This study aimed to develop a novel rice blast control strategy, which suppresses mutations in the pathogens, by studying the DNA recombination proteins in the pathogen. Results of this study indicated that DNA recombination is very important for the pathogen to cause the disease. DNA recombination proteins works as a complex will be a target for controlling the disease and suppressing the mutations. In this study, we also developed a screening system for inhibitors for protein-protein interaction.