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Modern reptiles with ancient toxins: the molecular origin and evolution of novel bioactive proteins from squamate dental glands.

Modern reptiles with ancient toxins: the molecular origin and evolution of novel bioactive proteins from squamate dental glands.
具有古老毒素的现代爬行动物:鳞状牙腺新型生物活性蛋白的分子起源和进化。
批准号:
DP0665971
负责人:
Prof Bryan Fry
金额:
$9.98万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2006
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2006-01-01 至 2008-12-31

项目摘要

项目成果

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中文摘要
翻译
动物毒液提供了丰富的新型生物活性蛋白来源,其中一些已被证明具有治疗作用。通过该研究人员的独特方法调查以前未绘制的鳞状毒液系统,有可能鉴定出不同的生物活性蛋白。申请人已经在澳大利亚巨蜥种类的牙腺中发现的那些代表了生物发现的巨大机会。这一领域的进一步知识将增加对咬伤的医学理解,并根据这些动物的自然史帮助采取保护措施。
英文摘要
Animal venoms provide a rich source of novel bioactive proteins, some of which have demonstrated therapeutically useful activities. Through this researcher's unique approach of investigating previously unmapped squamate venom systems, there is potential for the identification of divergent, bioactive proteins. Those already identified by the applicant in the dental glands of Australian monitor lizard species represent a tremendous opportunity for biodiscovery. Further knowledge in this area will increase medical understandings of bites and aid conservation measures informed by the natural history of these animals.
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海外基金