Evolutionary models and biodiscovery tools from neurotoxic snake venoms

神经毒性蛇毒的进化模型和生物发现工具

• 批准号: DP210102406
• 负责人: Prof Bryan Fry
• 金额: $ 42.06万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102406
• 关键词: Evolutionary; models; biodiscovery; tools; neurotoxic

This project aims to identify the selection pressures that shape snake venom neurotoxins and how they interact with nicotinic acetylcholine receptors, and to elucidate their biodiscovery potential. This project aims to test these important toxins on model systems that represent natural prey items in order to determine the molecular and functional evolution of neurotoxic peptides. Expected outcomes include substantial contributions to the body of evolutionary biology knowledge, while also having the applied benefit of discovering novel compounds with potential for use in drug design and discovery. These outcomes will benefit Australian science and society by elucidating fundamental processes while revealing biodisovery resources.

本项目旨在确定形成蛇毒神经毒素的选择压力及其如何与烟碱胆碱受体相互作用，并阐明其生物发现潜力。该项目旨在测试这些重要的毒素在代表自然猎物的模型系统上，以确定神经毒性肽的分子和功能进化。预期的结果包括对进化生物学知识的实质性贡献，同时也具有发现具有药物设计和发现潜力的新化合物的应用效益。这些成果将通过阐明基本过程，同时揭示生物发现资源，使澳大利亚科学和社会受益。