Functional evolution and therapeutic potential of snake venom coagulotoxins

蛇毒凝固毒素的功能进化和治疗潜力

• 批准号: DP190100304
• 负责人: Prof Bryan Fry
• 金额: $ 36.45万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-22 至 2022-02-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190100304
• 关键词: Functional; evolution; therapeutic; potential; snake

This project aims to identify and understand the factors that influence the useful function of key residues (parts of larger compounds) in Australian snake venom coagulotoxins, which alter blood-clotting ability. In recent years, snake venom compounds have been demonstrated as useful models from which to synthesise therapeutic drugs to improve health and well-being. This project will test these important toxins on model systems that represent natural prey items in order to determine the molecular and functional evolution of blood-clot forming enzymes. Expected outcomes include substantial contributions to the body of evolutionary biology knowledge, as well as narrowing the search for the ultimate drug candidates.

该项目旨在识别和了解影响澳大利亚蛇毒凝血毒素中关键残留物(较大化合物的部分)有用功能的因素。近年来，蛇毒化合物已被证明是合成治疗药物以改善健康和福祉的有用模型。该项目将在代表天然猎物的模型系统上测试这些重要的毒素，以确定血液凝块形成酶的分子和功能进化。预期结果包括对进化生物学知识体系的重大贡献，以及缩小对最终候选药物的搜索范围。