Evolutionary venomics: Venom system diversification in the animal kingdom

进化毒液组学：动物界毒液系统的多样化

• 批准号: DP0772814
• 负责人: Prof Bryan Fry
• 金额: $ 42.77万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-03-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0772814
• 关键词: Evolutionary; venomics; Venom; system; diversification

This proposal represents a tremendous opportunity for biodiscovery from the Australian toxic fauna. This will be achieved through the researcher's unique approach of investigating previously unmapped venom systems for divergent, bioactive proteins. An understanding of venomous animal protein evolution has practical implications for the treatment of envenomations - an enormous problem in Australia - as well as great potential in drug discovery and other commercial applications. This project will provide Australian graduate and post-graduate students with finely tuned skills in cutting edge methodological techniques and a fluent understanding of molecular evolution, preparing them to be internationally competitive scientists.

这一提议为澳大利亚有毒动物的生物发现提供了一个巨大的机会。这将通过研究人员独特的方法来实现，即研究以前未绘制的毒液系统，以寻找分歧的生物活性蛋白。了解有毒动物蛋白质的进化对于治疗毒物具有实际意义--这在澳大利亚是一个巨大的问题--以及在药物发现和其他商业应用方面的巨大潜力。该项目将为澳大利亚研究生和研究生提供尖端方法学技术的精细调整技能和对分子进化的流畅理解，为他们成为具有国际竞争力的科学家做好准备。