Multicatalytic synthesis with 1,3-dipoles in microfluidic systems

该研究项目旨在将光催化生成的1,3偶极子与多催化环境下的顺序进一步催化（对映选择性）转化（包括Lewis酸、有机催化和光催化）相结合，在顺序的一锅转化中获得有价值的、多功能化的杂环和无环构建块，分别对应的流动化学组合。微流控装置的重要性不仅在于其有益的效果，例如在提高生产力或改善光化学反应中的光穿透性方面，而且还应用于促进反应结果的监测。利用芯片实验室技术进行在线分离和分析，为反应和机理分析以及加速方法优化提供了新的见解。

The proposed research project aims at the combination of photocatalytically generated 1,3-dipoles with sequential further catalytic (enantioselective) transformations (including Lewis acid, organocatalysis as well as photocatalysis) in a multicatalytic setting to access valuable, multifunctionalized heterocycles and acyclic building blocks in sequential one-pot transformations, respectively corresponding flow chemistry combinations. Microfluidic set-ups are not only of importance due to their beneficial effects, e. g. in terms of increased productivity or improved light penetration in photochemical reactions, but should also be used here to facilitate the monitoring of the reaction outcome. Inline separation and analysis available from lab-on-a-chip technology is proposed to offer new insights in reaction and mechanistic analysis and accelerated method optimization.