Controllable dissolution of sol-gel derived borate glasses for accelerating wound healing

硼酸盐生物活性玻璃(Borate BGS)在临床上对慢性创面有显著的愈合效果。它们的溶解行为，即离子溶解产物的释放曲线和溶解速率，决定了伤口愈合的效果。良好控制的硼酸盐BGS的溶解行为可以促进伤口愈合。本研究的最终目的是通过调节玻璃成分来控制溶胶凝胶法制备的BG的溶解行为，从而达到加速创面愈合的目的。本项目将研究和确定玻璃成分与伤口愈合效果之间的关系，这对于阐明硼酸盐BGS愈合伤口的机制，即BGS的溶解行为至关重要。具体地说，考虑到含有生物活性离子Ca~(2+)(止血活性)、B~(3+)(血管生成活性)和Cu2+(抗菌和血管生成活性)的组成，将合成并表征一系列B_2O_3-CaO-CuO硼酸盐玻璃。基于Sol-Gel的方法将被用于合成BGS，因为Sol-Gel方法可以更好地控制合成的BGS的形貌。由于硼酸盐玻璃的溶解行为(溶解速率、离子释放)与其组成和结构密切相关，因此有望通过调整组成来调节和控制玻璃的溶解行为。为了了解复杂伤口愈合过程的成分依赖性，将评估玻璃的溶解产物对与伤口愈合相关的生物活性的影响，即止血活性、抗菌效果和血管生成潜力。通过完成该项目，通过控制玻璃的溶解行为有望达到加速伤口愈合的效果。通过本项目的实验计划，将对硼酸盐BGS的组成-溶解行为关系有更深入的了解。这样的理解将有助于阐明BGS对伤口愈合影响的潜在机制。考虑到溶胶凝胶法对BGS的形态和组成进行更好的控制，开发制备BGS的溶胶凝胶法将有利于开发先进的伤口愈合敷料。

Borate bioactive glasses (borate BGs) have shown impressive healing effects on chronic wounds clinically. Their dissolution behavior, in terms of the release profile of ionic dissolution products and dissolution rate, determines wound healing effects. A well-controlled dissolution behavior of borate BGs can accelerate wound healing. However, there has been no previous comprehensive study aiming at establishing the relationship between the dissolution behavior of borate BGs and wound healing effects.The final objective of this research project is to achieve accelerated wound healing by controlling the dissolution behavior of sol-gel derived borate BG through tuning glass compositions. The relationship between glass composition and wound healing effects, which is of paramount importance to be able to elucidate the mechanisms involved of borate BGs healing wounds, indeed the dissolution behavior of borate BGs, will be investigated and established in this project. Specifically, a series of B2O3-CaO-CuO borate glasses, considering the composition containing biologically active ions Ca2+ (hemostatic activity), B3+ (angiogenic activity), and Cu2+ (antibacterial and angiogenic activities), will be synthesized and characterized. Sol-gel based approaches will be used to synthesize borate BGs, given the better control in the morphology of synthesized BGs in the sol-gel approaches. Since the dissolution behavior (dissolution rates, ion release) of borate glasses is closely related to their composition and structure, it is expected to be able to tune and control glass dissolution behavior by tailoring the composition. To achieve the understanding of the compositional dependence of the complex wound healing process, the effects of the dissolution products of the glasses on the biological activities related to wound healing, i.e., hemostatic activity, antibacterial effect, and angiogenic potential, will be evaluated.By completing the project, accelerated wound healing effects are expected to be achieved by controlling the glass’s dissolution behavior. A deeper understanding of the composition-dissolution behavior relationship in borate BGs will be gained from the experimental program of this project. Such understanding will contribute to elucidating the mechanisms underlying the effects of borate BGs on wound healing. The development of sol-gel methods for producing borate BGs will be beneficial for developing advanced wound healing dressing, considering a better control in morphology and composition of BGs in the sol-gel approaches.