Additive manufacturing of bone replacement implants from crystallising bioactive glasses

由具有可调结晶的生物活性玻璃制造用于骨置换的植入物的增材制造（AM）能够实现复杂的形状、定制的孔隙率和腔体结构、治疗离子的释放、受控的材料降解以及对细胞形成和生长的良好刺激。尽管其具有许多有前途的优点，但几乎没有研究过通过结晶生物活性玻璃来进行增材制造。特别是，这种知识的缺乏包括AM工艺参数对制造过程中玻璃粉末压块的烧结、结晶和形状稳定性的影响。此外，结晶度，孔隙率和孔隙空间结构对生物活性的影响的基本知识是缺失的。因此，本项目的重点是从生物活性玻璃和它们的生物活性的复杂支架的AM。由于生物活性玻璃通常表现出强烈的结晶倾向，研究其对AM和生物活性的影响，包括细胞的形成，生长和材料降解是拟议的工作包的关键部分。

Additive manufacturing (AM) of implants for bone replacement from bioactive glasses with tuneable crystallisation enables complex shapes, tailored porosity and cavity architecture, the release of therapeutic ions, controlled materials degradation, and a good stimulus of cell formation and growth. Despite its numerous promising advantages, additive manufacturing from crystallising bioactive glasses has hardly been studied. In particular, this lack of knowledge comprises the effects of AM processing parameters on sintering, crystallisation, and shape stability of glass powder compacts during manufacture. Furthermore, fundamental knowledge about the influence of crystallinity, porosity and pore space architecture on bioactivity is missing. This project therefore focusses on the AM of complex scaffolds from bioactive glasses and their bioactivity. As bioactive glasses commonly exhibit strong crystallisation tendency, the study of its effect on AM and bioactivity including cell formation, growth and materials degradation is the key part of the proposed working packages.