Development of electrophoretic co-deposition of bioactive and antibacterial ceramics with biodegradable polymers to produce novel composite coatings for biomedical applications

开发生物活性抗菌陶瓷与可生物降解聚合物的电泳共沉积，以生产用于生物医学应用的新型复合涂层

• 批准号: 426494347
• 负责人: Professor Dr.-Ing. Aldo Boccaccini
• 金额: --
• 依托单位: Narodowe Centrum Nauki
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426494347?language=en
• 关键词: Development; electrophoretic; co; deposition; bioactive

The project aims to understand basic phenomena taking place during electrophoretic co-deposition of organic and inorganic particles with different size and morphology to obtain novel multicomponent biodegradable coatings with a balance of bioactive and antibacterial properties on titanium biomaterials. In particular, the mechanisms and kinetics of EPD will be investigated to fabricate homogeneous coatings with tailored microstructure. Characterisation of the coatings will be done to provide a fundamental understanding of the EPD parameters – micro/nanostructure – properties relationships. The proposed study complies the criteria of basic research and the main goal is to obtain a systematic, new knowledge about the influence of the EPD route on microstructure (phase composition) and surface topography of multicomponent biodegradable coatings as well as numerous properties, like coatings adhesion to the substrates, micro-mechanical and tribological properties, bioactivity and antibacterial properties as well as electrochemical corrosion resistance. This new knowledge will not only be useful for controlling the deposition process of coatings and to describe the interaction between the polymer and ceramic particles during co-deposition but also to obtain repetitive coatings with the intended microstructure and properties. These issues will provide a significant increase in the current state of knowledge in the field of materials science and biomedical engineering.

该项目旨在了解不同尺寸和形态的有机和无机颗粒的电泳共沉积过程中发生的基本现象，以获得在钛生物材料上具有生物活性和抗菌性能平衡的新型多组分生物降解涂层。特别是，EPD的机制和动力学将被研究，以制造具有定制微观结构的均匀涂层。将进行涂层的表征，以提供对EPD参数-微米/纳米结构-性质关系的基本理解。拟议的研究符合基础研究的标准，其主要目标是获得有关EPD路线对多组分生物可降解涂层的微观结构（相组成）和表面形貌以及众多性能（如涂层与基材的粘附性、微机械和摩擦学性能、生物活性和抗菌性能以及电化学耐腐蚀性）的影响的系统的新知识。这些新知识不仅有助于控制涂层的沉积过程和描述共沉积过程中聚合物和陶瓷颗粒之间的相互作用，而且有助于获得具有预期微观结构和性能的重复涂层。这些问题将在材料科学和生物医学工程领域的知识的当前状态提供显着增加。