From primary target inhibition to collapse of the cell envelope biosynthetic network (A10)

靶向肽聚糖前体脂质II可以诱导多因子细胞效应，超越细胞壁构建块的隔离。Teixobactin及相关抗生素靶向多种去戊烯基偶联脂质中间体，在靶标相互作用下诱导强裂解并形成超分子结构。它们产生耐药性的可能性也有限。我们将剖析teixobactin和teixobactin样抗生素诱导的细胞特征，并将其与其他细胞壁靶向抗生素进行比较。目的是在细胞和分子水平上揭示汇聚到高度相互联系的细胞壁生物合成网络崩溃的差异机制。

Targeting the peptidoglycan precursor lipid II can induce multifactorial cellular effects that go beyond sequestration of the cell wall building block. Teixobactin and related antibiotics target multiple undecaprenyl-coupled lipid intermediates, induce strong lysis and form supramolecular structures upon target interaction. They also have a limited potential for resistance development. We will dissect the cellular signatures induced by teixobactin and teixobactin-like antibiotics and compare these to other cell wall targeting antibiotics. The aim is to unravel on the cellular and molecular level differential mechanisms that converge onto the collapse of highly interlinked cell wall biosynthetic networks.