Measurement of Local Micro-Electroretinogram and Sequential Data Analysis

视网膜电信号(ERG)为临床眼科提供诊断信息。然而，由于强烈的闪光对整个区域的刺激，视网膜的部分活动并不能被显示出来，本研究提出了一种利用光电二极管(LED)刺激的新方法来分析局部微小ERG的频率特性。这种方法的优点是线性系统分析适用于计算机控制波形部分刺激诱发的MUERG。1990年，比较了正弦刺激的同步ERG的傅立叶分析和随机刺激的相关分析两种基本技术。1991年，利用相关分析技术对红色和橙色LED随机刺激引起的视网膜横轴MU ERG进行了分析。将最小二乘估计方法应用于由5个二阶传递函数组成的MUERG模型，实现了MUERG的分量分析。分析认为，Mu-ERG由与同花样ERG相似的分量波组成。1992年，我们分析了视网膜两部分诱发的muERG之间的相互作用。使用两个LED来刺激视网膜。先分别刺激中枢和外周部，然后同时刺激。实验结果的分析假设，对同时刺激的反应是由与个体反应相同的成分组成的。用最小二乘误差法分析表明，在可以忽略的静默期内，MUERGS之间存在抑制作用。

Electroretinogram(ERG) gives diagnostic information in the clinical ophthalomogy. However, the partial activities of the retina cannot be revealed, because of the whole area stimulation by powerful flush light.In this study, a new method using photodiode(LED) stimulation was proposed for analyzing the frequency characteristics of the local micro-ERG. Advantage of this method was applicability of linear system analysis to the mu ERG evoked by partial stimulation of computer controlled wave form.In 1990, two basic techniques, Fourier analysis of synchronous ERG to the sinusoidal stimulation and correlation analysis using random stimulation were compared. It was concluded that correlation analysis was more effectively to simplify the experimental procedure.In 1991, mu ERG evoked along the horizontal axis of the retina by random signal stimulation of red and orange LED was analyzed by wellknown correlation technique. Also, component analysis on the mu ERG was achieved applying the least square error estimation method to a mu ERG model consisted of five 2nd order transfer functions. It was concluded in the analysis that mu ERG consisted of similar component waves of the flush ERG. That is, the flush ERG corresponded to the spatial summation of mu ERG over whole retina.In 1992, interaction between mu ERGs evoked from two parts of the retina was analyzed. Two LEDs were used to stimulate the retina. The central and peripheral parts were stimulated at first time individually,and then simultaneously. The experimental results were analyzed on the assumption that the response to simultaneous stimulation was composed by the same components as those of the individual response. It was concluded from the analysis using least square error method that mu ERGs inhibitorily interacted within negligible silent period.