Laser photocoagulation treatment for choroidal neovascularization, experimental study

老年性盘状黄斑变性现在是老年人失明的主要原因。该病由脉络膜新生血管（ChNV）引起，激光光凝（PC）是唯一可行的治疗方法。我们用氪激光在猴子视网膜上实验制备了ChNV。本文尝试对这些实验性猴眼ChNV进行激光PC治疗，以确定每年激光PC治疗的最有效方法。其中，氩激光和染料激光（波长分别为577,590,830nm）对荧光素血管造影显示的ChNV网进行弱或强PC照射。术后3个月行临床及组织病理学检查。当PC较弱或不足时，新形成的血管保留在视网膜下间隙，病变未愈合。强烈或完全PC时，ChNV在病变处被湮没和消失，病变形成瘢痕愈合。氩激光PC不足，损伤内视网膜。577 nm和590 nm的染料激光对ChNV的遮挡效果最好。结果表明，Iriser光凝治疗脉络膜新生血管最有效，577 nm和590nm的染料激光，需要覆盖整个新生血管膜区域的强烈和完全的凝固来闭塞视网膜下的新生血管。这些结果在临床研究中具有重要意义。

Senile disciform macular degeneration is now a leading cause of blindness in the elderly people. The disease arises from choroidal neovascularization (ChNV), for which laser photocoagulation (PC) is only a expectable treatment. We produced ChNV experimentally in the monkey retinas with krypton laser PC. Laser PC treatments were attempted for these experimentally produced ChNV in the monkey eyes, to determine the most effective reannual in laser PC treatment.Among lasers, argon laser, and dye laser (wavelengths of 577, 590, 830 nm) were applied with weak or intense PC for ChNV nets which were revealed with fluorescein angiography. After PC, fundi were checked clinically and histapathologically for 3 months.With weak or insufficient PC, newly formed vessele had remained in the subretinal space and the lesion did not healed. With intense or complete PC, ChNV were obliterated and disappeared at the lesion, and the lesion become scarring to heal. Argon laser PC was insufficient and damaged to the inner retina. Dye lasers of 577 and 590 nm were most effective to occlude ChNV.These results showed that Iriser photocoagulation treatment for choroidal neovascularization, dye laser of 577 and 590 nm are most effective, and intense and complete coagulation covering the entire area of neovascular membrane is necessary to occlude the new vessel beneath the retina. These results indicate a significant information in clinical reannual.