RESEARCH FOR THE PATHOMECHANISM, EPIDEMILOGY AND TREATMENTS FOR HAM AND HTLV-I RELATED DISORDERS.

这项研究在这两年的调查中提供了几个重要的结果。在鹿儿岛的一个偏远岛屿笠里镇，我们调查了384名居民。其中血清中有抗htlv - 1抗体36例（9.4%）。未来10年将对携带者进行纵向研究。对鹿儿岛大学医院收治的800名患者及其家属进行了淋巴细胞分离。所有这些样品都储存在液氮中。将208例HAM患者的临床特征和实验室资料输入计算机进行分析。结果提供了一些关于HAM的重要信息。例如，HAM脑脊液中有时可能没有抗htlv - i抗体。分析HAM患者的相关疾病并计算其患病率。HTLV-I相关关节病、肺泡炎、干燥综合征、肌炎的发病机制。对IgA肾病和假性甲状旁腺功能减退进行了研究，得到了一些重要的发现。对5例尸检的HAM进行神经病理学分析。观察cd8淋巴细胞的特殊重要性。在患者血液中也发现了pX区域的细胞毒性CD8细胞。超过十种不同的治疗方案被尝试在HAM非常令人鼓舞的结果。

This research provided several important results during these two years of investigation. In Kasari-town, which is a remote island in Kagoshima, we examined 384 inhabitants. Among them, 36(9.4%) had anti-HTLV-I antibodies in the serum. A longitudinal study of carriers will be done in the coming ten years. Lymphocyte separation was performed from 800 patients and family members who were admitted at Kagoshima University hospital. All of these samples were stored in liquid nitrogen.The clinical features and the laboratory data of 208 patients with HAM were entered in the computer for analysis. The results provided several important information regarding HAM. For instance, HAM may not sometimes have anti-HTLV-I antibodies in cerebrospinal fluid. The associated diseases in patients with HAM were also analyzed and their prevalence were calculated. The pathomechanisms of HTLV-I associated arthropathy, alveolitis, Shjogren syndrome, myositis. IgA nephropathy and pseudohypoparathyroidism were investigated and several important findings could be obtained. Five autopsied cases HAM were studied for neuropathological analysis. The specific importance of CD8lymphocytes was observed. Cytotoxic CD8 cells for the pX region were also found in the blood of patients. More than ten different therapeutic regimens were tried in HAM with very encouraging results.