Basic and clinical studies on HTLV-I uveitis

这项研究的目的是确定人类T淋巴细胞病毒1型(HTLV-I)感染与根据传统诊断标准被归类为特发性葡萄膜炎的某些类型的相关性。特发性葡萄膜炎患者HTLV-I血清阳性率显著高于病原学明确的葡萄膜炎和非葡萄膜炎眼部疾病两个对照组。在HTLV-I流行区，特发性葡萄膜炎与HTLV-I感染的优势比在年轻年龄组(20-49岁)估计为11.0，而在老年组(50&lt；)为2.0。即使在HTLV-I较不流行的地区也记录了类似的观察结果。临床表现以中度玻璃体混浊、轻度虹膜炎和视网膜血管炎为主的中间葡萄膜炎。用聚合酶链式反应从所有受试患者的前房炎症细胞中检测到HTLV-I前病毒DNA，提示葡萄膜炎眼中存在HTLV-I感染细胞。

This study was aimed at determining the association of human T lymphotropic virus type 1 (HTLV-I) infection with certain type of uveitis that was classified as idiopathic on the basis of conventional diagnostic criteria. The seroprevalence of HTLV-I in idiopathic uveitis was significantly higher than that in two control groups, i. e. uveitis with defined etiology and non-uveitic ocular diseases. The odds ratio of idiopathic uveitis for HTLV-I infection was estimated to be 11.0 at younger aged group (20-49 years old), while being 2.0 at older aged group (50<) in an HTLV-I endemic area. A similar observation was recorded even in an HTLV-I less endemic area. Clinical features of the patients were characterized by intermediate uveitis consisting of moderate vitreous opacities, mild iritis and retinal vasculitis. Proviral DNA of HTLV-I was detected from inflammatory cells of the anterior chamber in all tested patients by polymerase chain reaction, suggesting the presence of HTLV-I infected cells in uveitic eyes.