Sero-epidemiology and gene-epidemiology of HBV/HCV infection in the hyper endemic area of chronic liverdiseascs.

对慢性肝病（慢性肝炎、肝硬化、肝细胞癌）标准死亡率高的地区进行HBV和/或HCV感染的血清流行病学和基因流行病学研究，得到以下结果：似乎SMR与HBV和/或HCV携带者患病率之间的相关性尚不清楚，即由慢性杠杆疾病引起的高SMR区域不一定显示HBV和/或HCV携带者的高患病率，反之亦然。临床诊断为无症状HCV携带者的献血者有2.799例。799例中诊断为慢性肝病527例（66%），其中肝细胞癌1例，肝硬化7例。研究HCV水平和/或垂直传播的发生率。在对总共80530名献血者进行的为期2年的随访研究中，没有出现水平传播病例，有2例（2.3%）HCV垂直传播，来自87名HCV携带者母亲。这些发现将为制定慢性肝病的控制策略提供依据。

Sero-epidemiological and gene-epidemiological studies of HBV and/or HCV infection were conducted in areas showing high Stamdard Mortality Rate (SMR) by chronic liver diseases (chronic hepatitis, liver cirrhosis and hepatocellular carcinoma) and the following results were obtained.1.It appears that the correlation between SMR and the prevalence of HBV and/or HCV carriers is not clear, that is, areas showing high SMR caused by chronic lever diseases do not necessarily show high prevalence of HBV and/or HCV carries, or vice versa. Further study is necessary to elucidate this point.2.799 asymptomatic HCV carriers selected from blood donors were clinically diagnosed. 527 (66%) out of 799 cases were diagnosed as chronic liver disease, with one case of hepatocellular carcinoma and 7 cases of liver cirrhosis.3.The incidence rate of horizontal and/or vertical HCV transmission was studied. In the 2-year follow up study of a total of 80,530 blood donors, there was no case of horizontal transmission and there were 2 (2.3%) cases of vertical HCV transmission from 87 HCV carrier mothers.These findings will provided the basis for establishing strategy for control of chronic liver diseases.