CHARGED LIPOSACCHARIDE BASED DRUG DELIVERY SYSTEM

药物与脂质和/或糖单元的复合代表了在这个新兴领域中正在研究的最重要的策略之一。增加亲水性化合物的脂溶性已被确定为改善其吸收的重要因素，因为它是穿过肠粘膜被动转运所必需的。糖单元的作用是非常重要的：（i）它改变物理化学性质（溶解度），（ii）利用主动转运系统（例如葡萄糖转运）和（iii）靶向化合物-“魔法BULET”（刘易斯X类似物-受损细胞）。从这些领域的革命性新技术中受益的医学和公共卫生领域是没有限制的。

Complexation of a drug with lipid and/or sugar units represents one of the most important of the strategies being investigated in this burgeoning field. Increasing the lipid solubility of a hydrophilic compound has been established as an important factor in improving its absorption as it is necessary for passive transport across intestinal mucosal membranes. The role of sugar unit is very important: (i) it modifies the physico-chemical properties (solubility), (ii) utilizes active transport systems (e.g. Glucose transport) and (iii) target the compound - "MAGIC BULET" (Lewis X analogues - damaged cells). There is no limit to the areas of medicine and public health that would benefit from revolutionary new technology in these areas.