Absorption and Excretion of Fluorine in Humans Due to Differences in absorption Route and Chemical Form of Fluoride

随着氟化物微量分析的最新进展，现在可以高精度地测定微量氟化物，例如血清中发现的氟化物。本研究采用血清氟化物水平和常用的尿氟化物水平作为氟化物吸收指标，研究了人体由于胃肠道、肺和皮肤等不同吸收途径以及各种氟化物的化学来源对氟化物的吸收情况。1)关于口服氟化物；胃肠道对NaF的吸收速度迅速而可观。另一方面，CaF_2的吸收率仅为NaF所示值的5-7%，AlF_3没有被吸收。产生这些差异的原因取决于各种氟化物的酸溶解度。2)关于呼吸吸收；研究了氟对NaF气溶胶、CaF_2气溶胶和气态HF的呼吸道吸收率。NaF的吸收率为23-26%，CaF_2的吸收率约为2%，hf的吸收率为10-80%。比较研究了HF、NH_4 HF和NaF溶液对豚鼠皮肤氟化率的影响。氢氟酸和氟化氢铵的皮肤吸收迅速而严重，而NaF溶液的皮肤吸收没有发生。

With the advent of recent advances in the microanalysis of fluoride, it is now possible to determination with high accuracy trace amount of fluoride,such as those found in the serum. In this study, the Absorption of fluoride in humans due to differences in absorption route, such as gastrointestinal tract, Lung and Skin et al. and chemical from of various fluorides are investgated by using serum fluoride level as well as the commonly used urinary fluoride levels as an indicator of fluoride absorption.1) On the oral administration of fluoride ; The rate of NaF absorption through the gastrointestinal tracts was rapid and considerable. On the other hand, the absorption rate of CaF_2 was only 5-7% of the value shown by NaF,and AlF_3 was not absorbed. The reason for these difference depends on the acid-solubulity of various fluorides.2) On the respiratory absorption ; The absorption rate of fluoride through the respiratory tract has been studied for NaF aerosol, CaF_2 aerosol and gaseous HF. The rate are estimated at 23-26% for NaF, about 2% for CaF_2 and 10-80% for HF.3) On the skin absorption ; A comparative study was made to look into the rate of fluoride into the quinea pig skin following administration of HF, NH_4 HF and NaF solution. The skin absorption of hydrofluolic acid and ammonium hydrogen fluoride were rapid and severe, but the skin absorption of NaF solution was not occurred.