Comparative study on the tumorigenicity of gallium arsenide,gallium phosphide and gallium oxide in hamsters following intratracheal instillation or in mice following intraperitoneal and subcutaneous injection.

本文报道了砷化镓（GaAs）和磷化镓（GaP）在雄性叙利亚金黄地鼠和雄性ICR小鼠体内的致瘤性，GaAs肺内滴注实验采用GaAs肺内滴注法，每周1次，共15周。总剂量为3.75mg。GaAs、GaP和Ga_2O_3皮下或腹腔注射给雄性ICR小鼠各一次，实验组小鼠的存活率明显低于对照组。给予的总剂量为48 mgGa/kg或480 mgGa/kg的每种药物悬浮在0.2ml橄榄油中。在背部注射的皮下组织中没有观察到肿瘤，并且在皮下切割后，各组的存活期与对照组相比没有显著差异 ...更多信息 无菌注射腹腔注射Ga_2O_3（480 mg Ga/kg）组的总肿瘤发生率与对照组相比有显著性差异。腹腔注射GaAs（480 mg Ga/kg）和Ga_2O_3（48 mg Ga/kg）组小鼠存活天数较对照组明显缩短。本研究中，虽然尚不清楚这是否增加了Ga_2O_3（480 mg Ga/kg）组小鼠腹腔注射GaAs和Ga_2O_3均表现出潜在的全身毒性。本文观察了砷化铟（InAs）和磷化铟（InP）对仓鼠肺组织的光镜和电镜改变。在光镜检查结果中，在肺中观察到的显著变化是肺泡壁和呼吸性细支气管上皮细胞上的肺泡上皮细胞显著增生，其向肺泡导管和邻近肺泡延伸。在扫描电镜下观察到的肺泡区的主要变化是InAs或InP颗粒的沉积，肺泡内巨噬细胞的积聚和肺泡壁的增厚，这些病变在肺泡区比在细支气管区更常见。少

Tumorigenicity of gallium arsenide (GaAs) and gallium phosphide (GaP) was studied in male Syrian golden hamsters or male ICR mice.In GaAs imtratracheal instillation study, GaAs was instilled into the lungs of male Syrian golden hamsters by intratracheal instillations once a week for 15 week. The total dosage were 3.75 mg Ss. Although GaAs had no apparant tumorigenicity, GaAs particulates were likely to produce relatively severe damage and the survival of the animals was shortened significantly compared with the control group.In GaAs, GaP and Ga_2O_3 subcutaneous or intraperitineal injection study, male ICR mice received once by a subcutaneous or intraperitoneal injection of each compound. the total doses given were 48 mg Ga/kg or 480 mg Ga/kg of each drug suspended in 0.2 ml of olive oil. No tumors were observed in the subcutis of the back injected, and there was no significant difference concerning the survival periods of each group compared with the control group following the subcut … More aneous injection. The total tumor incidence ub the Ga_2O_3 (480 mg Ga/kg) group of intraperitoneal injection was significantly different compared with the control group. In the GaAs (480 mg Ga/kg) and Ga_2O_3 (48 mg Ga/kg) group of intraperitoneal injection, the survival days of the mice were shortaned significantly compared with the control group. Trom this study, although it was not claear whether this increased production of total tumor in the Ga_2O_3 (480 mg Ga/kg) group was due to tumorigenic action of Ga_2O_3 itself or not, it appears that GaAs and Ga_2O_3 revealed potential systemic toxicity in mice following the intraperitoneal injection.In the morphological study, we investigated the light and electron microscopical changes of the lung in the hamsters instilled indium arsenide (InAs) or indium phosphide (InP) intratracheally. In the light microscopical findings, the prominent change observed in the lungs was marked proliferation of alveolar epitheliums on the alveolar wall and respiratory bronchiolar epitheliums, which extended towards alveolar ducts and neighboring alveoli. In the scanning electron microscopic findings, the main change observed in the alveolar region was the deposition of InAs or InP particulates, the accumulation of macrophages in the alveoli and the thickening the alveolar walls, which lesions were more frequently seen in the alveolar region than in the bronchiolar region. Less