Expulsion mechanism of adult-taeniid cestodes induced by mucosal responses of definitive hosts.

带绦虫不仅是因为它们在家畜中传播疾病，一些物种对公众健康也是非常重要的。到目前为止，对这些绦虫的抗性研究主要集中在中间宿主，因此也就是幼虫寄生虫阶段。其原因是尚未建立合适的最终宿主模型，而使用天然最终宿主的实验对柳南的健康构成了严重威胁，为安全的调查方法制造了障碍。为了克服这一问题，本实验室研究了从美国新墨西哥州获得的5种带绦科动物多房棘球绦虫(Em)、细粒棘球绦虫(Eg)、粗带绦虫(TC)、无尾棘球绦虫(Ts)和包虫病带绦虫(Th)、啮齿动物金黄地鼠(GH)、蒙古沙鼠(MG)和10种野生食肉啮齿类动物作为实验宿主的可能性。强的松龙处理和注射的仓鼠…的小肠内发育成虫2)TC/MG组。与生长激素组一样，治疗组小鼠排虫受阻。Em/GH组的卵子形成明显受阻。接种后第25天(PI)，经处理的生长激素可回收性成熟虫体。近交系小鼠对再感染存在防御反应。4)Em/MG组。易感性随宿主年龄的不同而不同，高回收率表明1-碘-Em/袋鼠等组的虫卵具有传染性。在感染的早期阶段，这些啮齿动物在蠕虫回收率和蠕虫发育方面与自然最终宿主相匹配。此外，首次建立了Em和Tc的完全替代最终宿主模型，我们可以开始解释驱虫和抗体反应之间的关联等现象。此外，通过在处理过的蒙古沙土鼠体内实现人绦虫T.saginata的生长到性成熟，我们打破了这一领域的研究障碍。较少

The taeniids are of interest not only because of their disease roll in domestic animals, some species are also of immense importance to Public health.To date, research on resistance to these cestodes has mainly focused on the intermediate host, and therefore on the larval cestode stage. The reasons for this were, that a suitable definitive host model has not been established, and experiments using the natural definitive host pose a grave threat to liuinan health, creating a barrier to safe investigative methods.To overcome this, this laboratory has investigated the possibility of using as experimental hosts for the five taeniid species Echinococcus multilocularis(Em), E. granulosus(Eg), Taenia crassiceps(Tc), T. saginata(Ts) and T. hydatigena(Th), the rodent species golden hamster(GH), Mongolian gerbil(MG) and 10 species of wild carnivorous rodents obtained from New Mexico, U.S.A.1) Tc/GH group. Adult worms developed in the small intestine of predonisolone treated and imtreated hamster … More s, and produced normal eggs.2) TC/MG group. In the treatment group worm expulsion was hindered as in the GH. A marked impediment to egg formation was noted.3) Em/GH group. Sexually mature worms were recovered from imtreated GH on day 25 post inoculation(PI). In inbred strains the presence of a defensive reaction to reinfection was suggested.4) Em/MG group. Susceptibility varied with age of host, and high worm recovery rate showed that the eggs liad Iiigli infectivity in this 1-iost.5) Em/Kangaroo rat etc. group. In tlie early stages of infection these rodents match the natural definitive host for worm recovery rate and worm development.Also, a complete substitute definitive host model for Em and Tc was established for the first time, and we could begin to explain phenomena such as the association between worm expulsion and antibody response.Apart from this, by achieving growth to sexual maturity of the human tapeworm T. saginata in treated Mongolian Gerbils, we have broken down the barriers to research in this field. Less