Effect of Lymphokine on Saltatory Nerve Conduction in Single Myelinated Nerve Fibers.

抗神经节苷脂抗体见于格林-巴利综合征和多灶性运动神经病的轴突形式。一些研究表明它们可能通过钠通道失活产生传导阻滞。为了证实这一观点，我们设计了一种方法来分析血清影响下单髓鞘纤维的跳跃传导。尽管有这样的前提，我们发现高效抗gm1兔血清检测的38条纤维中只有2条传导阻滞。未见人血清传导阻滞。与抗血清孵育的淋巴细胞产生的淋巴因子暴露后，25例中只有1例出现阻滞。这些发现不支持这些血清在这些疾病的发病机制中起重要作用的观点。

Antiganglioside antibodies are found in the axonal form of Guillain-Barre syndrome and multifocal motor neuropathy. Several studies indicated that they may produce conduction block through Na channel inactivation. To confirm this contention, we devised a method to analyze saltatory conduction in single myelinated fiber under the influence of the sera. Despite the premise, we found conduction block in only 2 out of 38 fibers examined with high-titer anti-GM1 rabbit serum. None showed conduction block by human sera. Only one out of 25 exhibited block after exposure to lymphokine produced by lymphocytes incubated with the anti sera. These finding do not support the view that these sera play an important role in the pathogenesis of these diseases.