A Study about the eticlogy of dural AVF using rat AVF model

使用我们的静脉性高血压大鼠研究了以下几点。1)应用免疫组织化学方法检测了人硬脑膜动静脉瘘患者（神经外科学报1996年出版）硬脑膜窦和静脉高压大鼠硬脑膜窦中碱性成纤维细胞生长因子（bFGF）的表达。bFGF在人和大鼠的硬脑膜窦壁中被发现。2）调节硬脑膜AVF发生的因子（雌激素）：雌激素与人硬脑膜AVF的发生有关。本实验比较了雌激素诱导的静脉高压大鼠AVF的发生率，结果表明，雌激素诱导的静脉高压大鼠AVF的发生率与未诱导的静脉高压大鼠AVF的发生率无显著差异。结论：雌激素本身并不影响硬脑膜AVF的发生。3）硬脑膜AVF发生的解剖学研究;静脉高压大鼠硬脑膜AVF血管三维构筑的扫描电镜研究。将Mercox（聚合物）注射到大鼠静脉窦中，但大鼠静脉窦的解剖太小，无法在不受伤的情况下取出。这项研究被放弃了。

Following points were studied using our venous hypertensive rats. 1) The mechanism of induced AVF by venous hypertension ; The appearance of basic fibroblast growth factor (bFGF) was examined by immunohistochemical technique for human dural sinus of dural AVF patients (Acta Neurochirurgica 1996 in press) and rat dural sinus of induced venous hypertension. bFGF was found in the sinus wall in human and rat dural sinus. This angiogenic factor may related to the development of dural AVF.2) The factor to modulate the development of dural AVF (estrogen) ; Estrogen is known to relate the development of human dural AVF.We examined the effect of estrogen for the development of rat dural AVFs. Induced venous hypertension rats with or without estrogen were compared at the rate of developing AVF.Any statistical significant difference was not revealed by this experiment. Therefore, we concluded estrogen itself did not affect the development of dural AVF.3) Anatomical study for the development of dural AVF ; Scanning electron microscopic study for the three dimensional angioarchitecture was studied for venous hypertension rat. Mercox (polymer) was injected into the rat venous sinus, but dessection of the rat venous sinus was too small to take out without injury. This study was abandoned.