Negative ion mass spectrometry: fundamentals and applied applications.

1. 我们寻求建立负离子质谱作为肽和蛋白质测序的主要技术工具。在这种情况下，我们将调查的结构和作用方式的肽复合物，这可能是重要的治疗和控制心脏病和中风。 2. 已知结构的负离子将被转换（在质谱仪中）为存在于星际冰和尘埃云中的瞬态（和反应性）分子。 这些分子的结构和化学性质对于理解这个星球上生命的起源非常重要。

1. We seek to establish negative ion mass spectrometry as a major technological tool for the sequencing of peptides and proteins. In this context, we will investigate the structures and modes of action of peptide complexes which may be of importance for the treatment and control of heart disease and stroke. 2. Negative ions of known structure will be converted (in the mass spectrometer) into transient (and reactive) molecules which are present in interstellar ice and dust clouds. The structures and chemistry of such molecules are of importance in understanding the origins of life on this planet.