Creation of Cementum Inducing peptide for functional Implant

本研究的目的是构建一种牙骨质诱导肽，用于功能性种植体，使其具有与天然牙相同的具有Sharpy纤维的牙骨质。我们利用Molclaft合成了具有与钛结合的钛结合蛋白（TBP-1）和与细胞整合素连接的RGD基序的人工蛋白。我们在Biomacromolecules（2008）上发表了这些体外结果。从这些结果表明，我们可以通过TBP-1在钛表面上结合钛表面上的各种蛋白质。在不久的将来，我们可以制造出具有牙周韧带样结构的功能性种植体。与此同时，锆代替钛成为了人们关注的植入材料，我们对锆结合蛋白和TBP进行了研究。

The purpose of this study was to create the cementum inducing peptide for functional implant which have a cementum with sharpy's fibers just same manner as natural tooth. We produced the artificial protein with Titanium-binding protein (TBP-1) which bind to the titanium, and RGD motif which connected to the integrin of the cells using Molclaft. We published these in vitro results on the Biomacromolecules (2008). From these results suggest that we could bind the various kinds of protein on the titanium surface on the titanium surface by TBP-1. In the near future, we could make a functional implant which have a periodontal ligament-like structure. In the mean time, Zirconium have given attention to implant materials instead of titanium, we investigate Zirconium binding protein as well as TBP.