Development of innovative method for diagnosing renal disease -Urinary Molecular Profiling-

本研究阐明在肾脏病理条件下，肾实质细胞掉落到尿液中。肾脏疾病模型和伴侣动物的尿细胞定量和定性模式与肾脏病理和功能的恶化相关。重要的是，这些尿细胞可以通过靶向尿液中mRNA和microRNA的分子生物学方法来检测。这些数据表明，基于尿细胞检测的尿液检测，在本研究中称为“尿液分子谱”，可能是肾脏疾病的无创诊断方法。

This study clarified that the renal parenchymal cells were dropped into urine in renal pathological conditions. The quantitative and qualitative urinary cellular patterns correlated with the deteriorations of renal pathology and function in renal disease models and companion animals. Importantly, these urinary cells could be detected by molecular biological methods targeting mRNA and microRNA in urine. These data indicated the possibility that the urinary tests based on the detections of urinary cells, entitled "Urinary Molecular Profiling" in the present study, could be noninvasive diagnosis methods for renal disease.